NERSC's mission is to accelerate scientific discovery at the DOE Office of Science through high performance computing and data analysis. 

As the mission scientific computing facility for the U.S. Department of Energy (DOE) Office of Science (SC), NERSC is the principal provider of high performance computing and data resources and services to its six program offices:

• Advanced Scientific Computing Research
• Basic Energy Sciences
• Biological and Environmental Research
• Fusion Energy Sciences
• High Energy Physics
• Nuclear Physics

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Fundamental to that mission is enabling computational science of scale, in which large, interdisciplinary teams of researchers attack fundamental problems in science and engineering that require massive calculations and that have broad scientific and economic impacts.